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endothelin and ventricular arrhythmias

Endothelin participates in the genesis of ischemic ventricular arrhythmias, both directly and by enhancing sympathetic activation. These actions are mediated by the ETA-receptor, whereas the role of ETB-receptor is under investigation.

amelioration of left ventricular remodeling by growth hormone, coupled with cellular therapy seeded in an alginate scaffold 

We are currently examining various strategies for the prevention of left ventricular remodeling post-myocardial infarction. Among these, growth hormone released locally via an implanted biomaterial scaffold has shown promising results.


prolonged intramyocardial GH ameliorates electrophysiologic remodeling in rats.
PhD Thesis of Dr Marianna Kontonika

watch video summarizing main results  >

There is a major demand for improved risk stratification post-MI.
Our collaborative group will examine the predictive accuracy of a novel algorithm
in patients with recent and remote MI.