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induction of myocardial infarction in the rat

•  Myocardial infarction in the rat-model is generated by ligation of the left coronary artery.
•  Ligation at its mid-segment elicits medium-sized necrosis, whereas more proximal sites result in larger area.
•  Instead of ligation, a snare is used in protocols involving reperfusion. 

MI induction in rats

The rat-model of myocardial infarction is useful in the study of ischemia-induced ventricular arrhythmias. It is also widely used in the investigation of treatments ameliorating post-MI LV remodeling.