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Langendorff preparations

A variety of parameters can be measured in the isolated, perfused heart preparation, providing useful information on left ventricular function and coronary flow. Over a century after its first description, the Langendorff technique continues to be a valuable tool in cardiac research.


ex vivo experiments

In Langendorff preparations, the isolated heart is perfused with oxygenated saline solutions at constant pressure or at constant flow. An intraventricular balloon is inserted, and the ventricle contracts isovolumetrically.
Parameters derived from the LV pressure provide assessment of LV function. Ventricular outflow correlates with coronary artery flow